Drug interactions
Ifosfamide + Tipranavir
Severity: Moderate
Ifosfamide and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, given with ritonavir, strongly affects CYP3A4, including induction, which can shift ifosfamide metabolism. This may change formation of the active alkylating metabolite and of the neurotoxic chloroacetaldehyde metabolite, so efficacy and toxicity are both unpredictable.
What this interaction means in plain words
Ifosfamide and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Tipranavir belongs to Anti Virals.
Why it happens
Modulation of CYP3A4 by tipranavir/ritonavir alters ifosfamide activation and toxic metabolite formation.
What to do
Use an alternative antiretroviral if possible. Otherwise monitor for ifosfamide neurotoxicity, myelosuppression and reduced response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Ifosfamide with Tipranavir?
MediHelp rates the interaction as moderate. Ifosfamide and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir, given with ritonavir, strongly affects CYP3A4, including induction, which can shift ifosfamide metabolism. This may change formation of the active alkylating metabolite and of the neurotoxic chloroacetaldehyde metabolite, so efficacy and toxicity are both unpredictable.
How serious is the interaction between Ifosfamide and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antiretroviral if possible. Otherwise monitor for ifosfamide neurotoxicity, myelosuppression and reduced response.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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