Drug interactions
Ifosfamide + Trastuzumab deruxtecan
Severity: Moderate
Ifosfamide and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause neutropenia, and trastuzumab deruxtecan can also cause left ventricular dysfunction and interstitial lung disease. Combined use raises the risk of cytopenias, infection and cardiac toxicity.
What this interaction means in plain words
Ifosfamide and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive myelosuppression and cardiotoxicity.
What to do
Monitor blood counts and cardiac function, and assess for respiratory symptoms. Adjust doses according to neutropenia and ejection fraction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Ifosfamide with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Ifosfamide and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause neutropenia, and trastuzumab deruxtecan can also cause left ventricular dysfunction and interstitial lung disease. Combined use raises the risk of cytopenias, infection and cardiac toxicity.
How serious is the interaction between Ifosfamide and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function, and assess for respiratory symptoms. Adjust doses according to neutropenia and ejection fraction.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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