Drug interactions
Ifosfamide + Voriconazole
Severity: Moderate
Ifosfamide and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide requires CYP3A4 activation, but it is also metabolized to neurotoxic and nephrotoxic metabolites by the same enzyme. Voriconazole may alter the balance of active and toxic metabolites, so the net effect on efficacy and toxicity is uncertain.
What this interaction means in plain words
Ifosfamide and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4, which changes the activation and toxic metabolite formation of ifosfamide.
What to do
Monitor for reduced response and for neurotoxicity or nephrotoxicity during combined therapy. Consider an alternative antifungal if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ifosfamide with Voriconazole?
MediHelp rates the interaction as moderate. Ifosfamide and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ifosfamide requires CYP3A4 activation, but it is also metabolized to neurotoxic and nephrotoxic metabolites by the same enzyme. Voriconazole may alter the balance of active and toxic metabolites, so the net effect on efficacy and toxicity is uncertain.
How serious is the interaction between Ifosfamide and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response and for neurotoxicity or nephrotoxicity during combined therapy. Consider an alternative antifungal if feasible.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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