Drug interactions
Iloperidone + Insulin degludec-liraglutide
Severity: Moderate
Iloperidone and Insulin degludec-liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics such as iloperidone can cause weight gain and hyperglycemia, although the risk with iloperidone is relatively modest. Glycemic control on insulin degludec/liraglutide may deteriorate.
What this interaction means in plain words
Iloperidone and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Insulin degludec-liraglutide belongs to Endocrine.
Why it happens
Antipsychotic-related insulin resistance and metabolic effects oppose antidiabetic therapy.
What to do
Monitor fasting glucose and HbA1c after starting iloperidone. Adjust antidiabetic doses when needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Insulin degludec-liraglutide?
MediHelp rates the interaction as moderate. Iloperidone and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atypical antipsychotics such as iloperidone can cause weight gain and hyperglycemia, although the risk with iloperidone is relatively modest. Glycemic control on insulin degludec/liraglutide may deteriorate.
How serious is the interaction between Iloperidone and Insulin degludec-liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting iloperidone. Adjust antidiabetic doses when needed.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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