Drug interactions
Iloperidone + Insulin degludec
Severity: Moderate
Iloperidone and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics can cause hyperglycemia and worsen diabetes control. Insulin degludec doses may need to be increased.
What this interaction means in plain words
Iloperidone and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Insulin degludec belongs to Endocrine.
Why it happens
Antipsychotic-associated insulin resistance and altered glucose metabolism; the exact mechanism is not fully defined.
What to do
Monitor glucose regularly, particularly after starting iloperidone or changing the dose. Adjust insulin degludec as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Insulin degludec?
MediHelp rates the interaction as moderate. Iloperidone and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atypical antipsychotics can cause hyperglycemia and worsen diabetes control. Insulin degludec doses may need to be increased.
How serious is the interaction between Iloperidone and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose regularly, particularly after starting iloperidone or changing the dose. Adjust insulin degludec as needed.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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