Drug interactions
Iloperidone + Insulin glargine-lixisenatide
Severity: Moderate
Iloperidone and Insulin glargine-lixisenatide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics such as iloperidone can cause hyperglycemia and weight gain, which may offset the effect of insulin glargine and lixisenatide. Glycemic control can deteriorate in patients with diabetes.
What this interaction means in plain words
Iloperidone and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Insulin glargine-lixisenatide belongs to Endocrine.
Why it happens
Antipsychotic-related insulin resistance and metabolic effects produce pharmacodynamic antagonism of the antidiabetic agents.
What to do
Monitor fasting glucose and HbA1c after starting iloperidone and titrate antidiabetic therapy accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Insulin glargine-lixisenatide?
MediHelp rates the interaction as moderate. Iloperidone and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atypical antipsychotics such as iloperidone can cause hyperglycemia and weight gain, which may offset the effect of insulin glargine and lixisenatide. Glycemic control can deteriorate in patients with diabetes.
How serious is the interaction between Iloperidone and Insulin glargine-lixisenatide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting iloperidone and titrate antidiabetic therapy accordingly.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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