Drug interactions
Iloperidone + Isosorbide dinitrate
Severity: Moderate
Iloperidone and Isosorbide dinitrate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone inhibits CYP3A4, but this is a minor route for isosorbide dinitrate. Iloperidone also causes orthostatic hypotension, which may add to the nitrate's blood pressure lowering.
What this interaction means in plain words
Iloperidone and Isosorbide dinitrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Isosorbide dinitrate belongs to Cardiovascular.
Why it happens
Additive hypotensive effects, with minor CYP3A4 inhibition.
What to do
Monitor blood pressure and orthostatic symptoms, especially at initiation and dose increases. Counsel patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isosorbide dinitrate
- Avanafil + Isosorbide dinitrate Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Ergotamine + Isosorbide dinitrate Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Isosorbide dinitrate?
MediHelp rates the interaction as moderate. Iloperidone and Isosorbide dinitrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone inhibits CYP3A4, but this is a minor route for isosorbide dinitrate. Iloperidone also causes orthostatic hypotension, which may add to the nitrate's blood pressure lowering.
How serious is the interaction between Iloperidone and Isosorbide dinitrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, especially at initiation and dose increases. Counsel patients to rise slowly.
What other medicines interact with Isosorbide dinitrate?
MediHelp also lists interactions of Isosorbide dinitrate with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Isosorbide dinitrate page.
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