Drug interactions
Iloperidone + Lorazepam
Severity: Moderate
Iloperidone and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is an atypical antipsychotic that causes somnolence and orthostatic hypotension. With lorazepam, sedation and hypotension may be additive, raising the risk of falls and syncope.
What this interaction means in plain words
Iloperidone and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Lorazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression and alpha-1 adrenergic blockade by iloperidone together with GABA-A potentiation by lorazepam.
What to do
Monitor for sedation and orthostatic blood pressure changes, particularly during dose titration, and counsel patients on rising slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Lorazepam?
MediHelp rates the interaction as moderate. Iloperidone and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is an atypical antipsychotic that causes somnolence and orthostatic hypotension. With lorazepam, sedation and hypotension may be additive, raising the risk of falls and syncope.
How serious is the interaction between Iloperidone and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic blood pressure changes, particularly during dose titration, and counsel patients on rising slowly.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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