Drug interactions
Iloperidone + Metformin-repaglinide
Severity: Moderate
Iloperidone and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone, an atypical antipsychotic, can cause hyperglycemia and weight gain, working against the glycemic control of metformin and repaglinide. It is also a weak time-dependent CYP3A inhibitor that may modestly raise repaglinide levels. Net effects on glucose can be unpredictable.
What this interaction means in plain words
Iloperidone and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Metformin-repaglinide belongs to Endocrine.
Why it happens
Antipsychotic-induced insulin resistance and impaired glucose tolerance oppose antidiabetic effect, plus mild CYP3A inhibition of repaglinide metabolism.
What to do
Monitor fasting glucose and HbA1c after starting iloperidone and adjust antidiabetic therapy. Watch for hypoglycemia with repaglinide.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Iloperidone and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone, an atypical antipsychotic, can cause hyperglycemia and weight gain, working against the glycemic control of metformin and repaglinide. It is also a weak time-dependent CYP3A inhibitor that may modestly raise repaglinide levels. Net effects on glucose can be unpredictable.
How serious is the interaction between Iloperidone and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting iloperidone and adjust antidiabetic therapy. Watch for hypoglycemia with repaglinide.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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