Drug interactions
Iloperidone + Morphine
Severity: Moderate
Iloperidone and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is a sedating antipsychotic with alpha-blocking activity, and combining it with morphine adds to central nervous system depression. Drowsiness, dizziness, orthostatic hypotension and impaired psychomotor performance may be more pronounced.
What this interaction means in plain words
Iloperidone and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Morphine belongs to Musculoskeletal.
Why it happens
Additive CNS depressant and hypotensive effects through different receptor pathways.
What to do
Start with the lowest effective doses and titrate carefully, monitoring sedation, blood pressure and respiratory rate. Advise patients to rise slowly and avoid driving or hazardous tasks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Morphine?
MediHelp rates the interaction as moderate. Iloperidone and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is a sedating antipsychotic with alpha-blocking activity, and combining it with morphine adds to central nervous system depression. Drowsiness, dizziness, orthostatic hypotension and impaired psychomotor performance may be more pronounced.
How serious is the interaction between Iloperidone and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective doses and titrate carefully, monitoring sedation, blood pressure and respiratory rate. Advise patients to rise slowly and avoid driving or hazardous tasks.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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