Drug interactions
Iloperidone + Nifedipine
Severity: Moderate
Iloperidone and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is a weak time-dependent CYP3A inhibitor and may modestly raise nifedipine exposure, increasing hypotension, flushing and edema. Both drugs can lower blood pressure, and iloperidone causes orthostatic hypotension, so additive effects are plausible.
What this interaction means in plain words
Iloperidone and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Nifedipine belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by iloperidone reduces nifedipine clearance, combined with additive hypotensive pharmacodynamic effects.
What to do
Monitor blood pressure and orthostatic symptoms, especially when starting or titrating either drug. Reduce the nifedipine dose if hypotension or marked edema occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Nifedipine?
MediHelp rates the interaction as moderate. Iloperidone and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is a weak time-dependent CYP3A inhibitor and may modestly raise nifedipine exposure, increasing hypotension, flushing and edema. Both drugs can lower blood pressure, and iloperidone causes orthostatic hypotension, so additive effects are plausible.
How serious is the interaction between Iloperidone and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, especially when starting or titrating either drug. Reduce the nifedipine dose if hypotension or marked edema occurs.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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