Drug interactions
Iloperidone + Oxazepam
Severity: Moderate
Iloperidone and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone can cause somnolence, dizziness and orthostatic hypotension, and a benzodiazepine adds to these effects. This raises the risk of oversedation, falls and impaired cognition.
What this interaction means in plain words
Iloperidone and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Oxazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotension from GABA-A potentiation and alpha-1/histamine receptor antagonism.
What to do
Monitor for sedation and orthostatic hypotension, especially during iloperidone titration. Counsel patients on rising slowly and avoiding driving until tolerance is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Oxazepam?
MediHelp rates the interaction as moderate. Iloperidone and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone can cause somnolence, dizziness and orthostatic hypotension, and a benzodiazepine adds to these effects. This raises the risk of oversedation, falls and impaired cognition.
How serious is the interaction between Iloperidone and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic hypotension, especially during iloperidone titration. Counsel patients on rising slowly and avoiding driving until tolerance is known.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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