Drug interactions
Iloperidone + Pazopanib
Severity: Moderate
Iloperidone and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone may weakly inhibit CYP3A4 and may modestly increase pazopanib exposure. Both drugs also prolong the QT interval, so arrhythmia risk is additive.
What this interaction means in plain words
Iloperidone and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Pazopanib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by iloperidone plus additive QT prolongation.
What to do
Monitor ECG and electrolytes and watch for pazopanib toxicity such as hepatotoxicity. Avoid the combination in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Pazopanib?
MediHelp rates the interaction as moderate. Iloperidone and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone may weakly inhibit CYP3A4 and may modestly increase pazopanib exposure. Both drugs also prolong the QT interval, so arrhythmia risk is additive.
How serious is the interaction between Iloperidone and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes and watch for pazopanib toxicity such as hepatotoxicity. Avoid the combination in patients with other QT risk factors.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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