Drug interactions
Iloperidone + Phenelzine
Severity: Moderate
Iloperidone and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an MAO inhibitor with an antipsychotic may increase serotonergic activity and the risk of serotonin syndrome, and may add to the risk of neuroleptic malignant syndrome. Additive hypotension and sedation can also occur.
What this interaction means in plain words
Iloperidone and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Why it happens
Increased serotonergic tone from MAO inhibition combined with dopamine and serotonin receptor antagonism by iloperidone.
What to do
Monitor for mental status change, hyperthermia, rigidity, clonus and autonomic instability, especially after dose changes. Monitor blood pressure and consider ECG, as iloperidone prolongs QT.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Phenelzine?
MediHelp rates the interaction as moderate. Iloperidone and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an MAO inhibitor with an antipsychotic may increase serotonergic activity and the risk of serotonin syndrome, and may add to the risk of neuroleptic malignant syndrome. Additive hypotension and sedation can also occur.
How serious is the interaction between Iloperidone and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mental status change, hyperthermia, rigidity, clonus and autonomic instability, especially after dose changes. Monitor blood pressure and consider ECG, as iloperidone prolongs QT.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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