Drug interactions
Iloperidone + Pioglitazone
Severity: Moderate
Iloperidone and Pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone, like other atypical antipsychotics, can worsen glycemic control and may counteract the effect of pioglitazone. Weight gain and metabolic changes may further complicate diabetes management.
What this interaction means in plain words
Iloperidone and Pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Pioglitazone belongs to Endocrine.
Why it happens
Atypical antipsychotics induce insulin resistance and metabolic changes that oppose antidiabetic therapy.
What to do
Monitor fasting glucose, HbA1c and weight after starting iloperidone. Adjust the antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pioglitazone
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Pioglitazone?
MediHelp rates the interaction as moderate. Iloperidone and Pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone, like other atypical antipsychotics, can worsen glycemic control and may counteract the effect of pioglitazone. Weight gain and metabolic changes may further complicate diabetes management.
How serious is the interaction between Iloperidone and Pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose, HbA1c and weight after starting iloperidone. Adjust the antidiabetic regimen as needed.
What other medicines interact with Pioglitazone?
MediHelp also lists interactions of Pioglitazone with, for example, Insulin aspart-insulin aspart protamine, Insulin aspart, Insulin degludec-insulin aspart. The full list is on the Pioglitazone page.
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