Drug interactions
Iloperidone + Ropinirole
Severity: Moderate
Iloperidone and Ropinirole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone blocks dopamine D2 receptors and can counteract ropinirole's dopaminergic effect. This may worsen parkinsonian symptoms or reduce effectiveness in restless legs syndrome.
What this interaction means in plain words
Iloperidone and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Ropinirole belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at dopamine D2 receptors.
What to do
Avoid in Parkinson disease and choose quetiapine or clozapine for psychosis if needed. Otherwise monitor motor symptoms and adjust ropinirole as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Ropinirole?
MediHelp rates the interaction as moderate. Iloperidone and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone blocks dopamine D2 receptors and can counteract ropinirole's dopaminergic effect. This may worsen parkinsonian symptoms or reduce effectiveness in restless legs syndrome.
How serious is the interaction between Iloperidone and Ropinirole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in Parkinson disease and choose quetiapine or clozapine for psychosis if needed. Otherwise monitor motor symptoms and adjust ropinirole as required.
What other medicines interact with Ropinirole?
MediHelp also lists interactions of Ropinirole with, for example, Amisulpride, Chlorpromazine, Droperidol. The full list is on the Ropinirole page.
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