Drug interactions
Iloperidone + Salmeterol
Severity: Moderate
Iloperidone and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is a weak time-dependent CYP3A4 inhibitor and may modestly raise systemic salmeterol exposure. Higher salmeterol levels can increase tachycardia, tremor and QT effects. Iloperidone itself also prolongs the QT interval, so additive cardiac risk is possible.
What this interaction means in plain words
Iloperidone and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Salmeterol belongs to Respiratory.
Why it happens
Iloperidone inhibits CYP3A4-mediated metabolism of salmeterol, with possible additive QT prolongation.
What to do
Monitor heart rate, palpitations and ECG in patients with cardiac risk factors. Reduce salmeterol use if beta-agonist adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Salmeterol?
MediHelp rates the interaction as moderate. Iloperidone and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is a weak time-dependent CYP3A4 inhibitor and may modestly raise systemic salmeterol exposure. Higher salmeterol levels can increase tachycardia, tremor and QT effects. Iloperidone itself also prolongs the QT interval, so additive cardiac risk is possible.
How serious is the interaction between Iloperidone and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, palpitations and ECG in patients with cardiac risk factors. Reduce salmeterol use if beta-agonist adverse effects appear.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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