Drug interactions
Iloperidone + Scopolamine
Severity: Moderate
Iloperidone and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone has modest anticholinergic and sedating effects, and scopolamine adds antimuscarinic and CNS activity. The combination can increase dry mouth, constipation, urinary retention, confusion and drowsiness, and may blunt antipsychotic effect. Iloperidone also carries QT prolongation risk and orthostatic hypotension.
What this interaction means in plain words
Iloperidone and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Scopolamine belongs to Respiratory.
Why it happens
Additive antimuscarinic and CNS depressant effects.
What to do
Monitor for anticholinergic effects, sedation and psychiatric response. Use the lowest effective doses, particularly in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Scopolamine?
MediHelp rates the interaction as moderate. Iloperidone and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone has modest anticholinergic and sedating effects, and scopolamine adds antimuscarinic and CNS activity. The combination can increase dry mouth, constipation, urinary retention, confusion and drowsiness, and may blunt antipsychotic effect. Iloperidone also carries QT prolongation risk and orthostatic hypotension.
How serious is the interaction between Iloperidone and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects, sedation and psychiatric response. Use the lowest effective doses, particularly in older adults.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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