Drug interactions
Iloperidone + Selegiline
Severity: Moderate
Iloperidone and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents act on dopamine and serotonin pathways. Selegiline's dopaminergic effect opposes antipsychotic D2 blockade, which may worsen psychosis or parkinsonism. Rare serotonin syndrome or neuroleptic malignant syndrome has been described with similar combinations.
What this interaction means in plain words
Iloperidone and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Why it happens
Pharmacodynamic opposition at dopamine receptors combined with additive serotonergic effects.
What to do
Monitor for mental status change, rigidity, hyperthermia and autonomic instability, and for worsening of psychosis or motor symptoms. Stop one or both drugs if serotonin syndrome or NMS is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Selegiline?
MediHelp rates the interaction as moderate. Iloperidone and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents act on dopamine and serotonin pathways. Selegiline's dopaminergic effect opposes antipsychotic D2 blockade, which may worsen psychosis or parkinsonism. Rare serotonin syndrome or neuroleptic malignant syndrome has been described with similar combinations.
How serious is the interaction between Iloperidone and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mental status change, rigidity, hyperthermia and autonomic instability, and for worsening of psychosis or motor symptoms. Stop one or both drugs if serotonin syndrome or NMS is suspected.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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