Drug interactions
Iloperidone + Terazosin
Severity: Moderate
Iloperidone and Terazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone has potent alpha-1 adrenergic antagonism, which adds to the effect of terazosin. Orthostatic hypotension, dizziness, and syncope are more likely, especially during initiation and dose escalation.
What this interaction means in plain words
Iloperidone and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Terazosin belongs to Genitourinary.
Why it happens
Additive alpha-1 adrenergic receptor blockade.
What to do
Titrate iloperidone slowly and monitor orthostatic blood pressure; reduce the terazosin dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terazosin
- Alfuzosin + Terazosin Major
- Amifostine + Terazosin Major
- Avanafil + Terazosin Major
- Doxazosin + Terazosin Major
- Dutasteride-tamsulosin + Terazosin Major
- Lofexidine + Terazosin Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Terazosin?
MediHelp rates the interaction as moderate. Iloperidone and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone has potent alpha-1 adrenergic antagonism, which adds to the effect of terazosin. Orthostatic hypotension, dizziness, and syncope are more likely, especially during initiation and dose escalation.
How serious is the interaction between Iloperidone and Terazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate iloperidone slowly and monitor orthostatic blood pressure; reduce the terazosin dose if symptomatic hypotension occurs.
What other medicines interact with Terazosin?
MediHelp also lists interactions of Terazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Terazosin page.
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