Drug interactions
Iloperidone + Trospium
Severity: Minor
Iloperidone and Trospium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone has modest anticholinergic activity that may add to trospium's effects, producing constipation, dry mouth or urinary retention. The reported absorption and antagonism effects are not clinically established.
What this interaction means in plain words
Iloperidone and Trospium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Iloperidone belongs to Central Nervous System; Trospium belongs to Genitourinary.
Why it happens
Weak additive antimuscarinic effects; no established pharmacokinetic interaction.
What to do
Monitor for anticholinergic symptoms such as constipation and urinary retention; no dose adjustment is generally needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trospium
- Clozapine + Trospium Major
- Pramlintide + Trospium Major
- Thioridazine + Trospium Major
- Trihexyphenidyl + Trospium Major
- Aclidinium + Trospium Moderate
- Amantadine + Trospium Moderate
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Trospium?
MediHelp rates the interaction as minor. Iloperidone and Trospium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone has modest anticholinergic activity that may add to trospium's effects, producing constipation, dry mouth or urinary retention. The reported absorption and antagonism effects are not clinically established.
How serious is the interaction between Iloperidone and Trospium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic symptoms such as constipation and urinary retention; no dose adjustment is generally needed.
What other medicines interact with Trospium?
MediHelp also lists interactions of Trospium with, for example, Clozapine, Pramlintide, Thioridazine. The full list is on the Trospium page.
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