Drug interactions
Iloperidone + Vinorelbine
Severity: Minor
Iloperidone and Vinorelbine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is a weak time-dependent CYP3A inhibitor and may slightly raise vinorelbine exposure. Increased myelosuppression or neurotoxicity is possible but likely modest.
What this interaction means in plain words
Iloperidone and Vinorelbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Iloperidone belongs to Central Nervous System; Vinorelbine belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by iloperidone reduces vinorelbine metabolism.
What to do
Monitor blood counts and neuropathy as per routine vinorelbine care. Reduce the vinorelbine dose if toxicity occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vinorelbine
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Vinorelbine?
MediHelp rates the interaction as minor. Iloperidone and Vinorelbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone is a weak time-dependent CYP3A inhibitor and may slightly raise vinorelbine exposure. Increased myelosuppression or neurotoxicity is possible but likely modest.
How serious is the interaction between Iloperidone and Vinorelbine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy as per routine vinorelbine care. Reduce the vinorelbine dose if toxicity occurs.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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