Drug interactions
Iloprost + Imipramine
Severity: Moderate
Iloprost and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloprost is a potent vasodilator and imipramine can cause orthostatic hypotension through alpha-adrenergic blockade. Together they may produce additive blood pressure lowering, dizziness or syncope.
What this interaction means in plain words
Iloprost and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloprost belongs to Cardiovascular; Imipramine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from prostacyclin-mediated vasodilation and alpha-1 adrenergic blockade.
What to do
Monitor blood pressure and heart rate, particularly when starting or titrating iloprost. Reduce the iloprost dose or review imipramine if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Iloprost
- Aldesleukin + Iloprost Moderate
- Amiodarone + Iloprost Moderate
- Bortezomib + Iloprost Moderate
- Bromocriptine + Iloprost Moderate
- Bupivacaine + Iloprost Moderate
- Carbidopa-entacapone-levodopa + Iloprost Moderate
Frequently asked questions
Can I take Iloprost with Imipramine?
MediHelp rates the interaction as moderate. Iloprost and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloprost is a potent vasodilator and imipramine can cause orthostatic hypotension through alpha-adrenergic blockade. Together they may produce additive blood pressure lowering, dizziness or syncope.
How serious is the interaction between Iloprost and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, particularly when starting or titrating iloprost. Reduce the iloprost dose or review imipramine if symptomatic hypotension occurs.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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