Drug interactions
Iloprost + Isocarboxazid
Severity: Moderate
Iloprost and Isocarboxazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both can lower blood pressure, and intravenous iloprost may cause significant hypotension when given with other blood-pressure-lowering drugs. MAOIs also cause orthostatic hypotension.
What this interaction means in plain words
Iloprost and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloprost belongs to Cardiovascular; Isocarboxazid belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from vasodilation and MAOI-related autonomic effects.
What to do
Monitor blood pressure during iloprost infusion and reduce the iloprost dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Other interactions of Iloprost
- Aldesleukin + Iloprost Moderate
- Amiodarone + Iloprost Moderate
- Bortezomib + Iloprost Moderate
- Bromocriptine + Iloprost Moderate
- Bupivacaine + Iloprost Moderate
- Carbidopa-entacapone-levodopa + Iloprost Moderate
Frequently asked questions
Can I take Iloprost with Isocarboxazid?
MediHelp rates the interaction as moderate. Iloprost and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both can lower blood pressure, and intravenous iloprost may cause significant hypotension when given with other blood-pressure-lowering drugs. MAOIs also cause orthostatic hypotension.
How serious is the interaction between Iloprost and Isocarboxazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during iloprost infusion and reduce the iloprost dose if hypotension develops.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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