Drug interactions
Iloprost + Isosorbide mononitrate
Severity: Moderate
Iloprost and Isosorbide mononitrate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents dilate blood vessels, so combining them may cause additive lowering of blood pressure. The risk is greatest with intravenous iloprost.
What this interaction means in plain words
Iloprost and Isosorbide mononitrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloprost belongs to Cardiovascular; Isosorbide mononitrate belongs to Cardiovascular.
Why it happens
Additive vasodilation via prostacyclin receptor activation and nitric oxide/cGMP signalling.
What to do
Monitor blood pressure during iloprost therapy and consider temporarily holding the nitrate if hypotension occurs. Reduce or stop iloprost if hypotension persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isosorbide mononitrate
- Avanafil + Isosorbide mononitrate Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Sildenafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Ergotamine + Isosorbide mononitrate Major
Other interactions of Iloprost
- Aldesleukin + Iloprost Moderate
- Amiodarone + Iloprost Moderate
- Bortezomib + Iloprost Moderate
- Bromocriptine + Iloprost Moderate
- Bupivacaine + Iloprost Moderate
- Carbidopa-entacapone-levodopa + Iloprost Moderate
Frequently asked questions
Can I take Iloprost with Isosorbide mononitrate?
MediHelp rates the interaction as moderate. Iloprost and Isosorbide mononitrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents dilate blood vessels, so combining them may cause additive lowering of blood pressure. The risk is greatest with intravenous iloprost.
How serious is the interaction between Iloprost and Isosorbide mononitrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during iloprost therapy and consider temporarily holding the nitrate if hypotension occurs. Reduce or stop iloprost if hypotension persists.
What other medicines interact with Isosorbide mononitrate?
MediHelp also lists interactions of Isosorbide mononitrate with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Isosorbide mononitrate page.
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