Drug interactions
Iloprost + Lofexidine
Severity: Moderate
Iloprost and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both lofexidine and iloprost lower blood pressure, so together they may cause additive hypotension. This is most relevant with intravenous iloprost.
What this interaction means in plain words
Iloprost and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloprost belongs to Cardiovascular; Lofexidine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from central alpha-2 agonism and prostacyclin-mediated vasodilation.
What to do
Monitor blood pressure during iloprost administration and consider temporarily holding lofexidine. Reduce or stop iloprost if hypotension persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Other interactions of Iloprost
- Aldesleukin + Iloprost Moderate
- Amiodarone + Iloprost Moderate
- Bortezomib + Iloprost Moderate
- Bromocriptine + Iloprost Moderate
- Bupivacaine + Iloprost Moderate
- Carbidopa-entacapone-levodopa + Iloprost Moderate
Frequently asked questions
Can I take Iloprost with Lofexidine?
MediHelp rates the interaction as moderate. Iloprost and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both lofexidine and iloprost lower blood pressure, so together they may cause additive hypotension. This is most relevant with intravenous iloprost.
How serious is the interaction between Iloprost and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during iloprost administration and consider temporarily holding lofexidine. Reduce or stop iloprost if hypotension persists.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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