Drug interactions
Iloprost + Minoxidil
Severity: Moderate
Iloprost and Minoxidil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure through vasodilation, so combined use can cause additive hypotension. The risk is greatest during intravenous iloprost infusion.
What this interaction means in plain words
Iloprost and Minoxidil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloprost belongs to Cardiovascular; Minoxidil belongs to Cardiovascular.
Why it happens
Additive vasodilation from iloprost (prostacyclin analogue) and minoxidil (potassium channel opener).
What to do
Monitor blood pressure and heart rate during iloprost initiation and titration. Consider temporarily holding minoxidil during IV iloprost and reduce the iloprost dose if hypotension persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Minoxidil
Other interactions of Iloprost
- Aldesleukin + Iloprost Moderate
- Amiodarone + Iloprost Moderate
- Bortezomib + Iloprost Moderate
- Bromocriptine + Iloprost Moderate
- Bupivacaine + Iloprost Moderate
- Carbidopa-entacapone-levodopa + Iloprost Moderate
Frequently asked questions
Can I take Iloprost with Minoxidil?
MediHelp rates the interaction as moderate. Iloprost and Minoxidil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure through vasodilation, so combined use can cause additive hypotension. The risk is greatest during intravenous iloprost infusion.
How serious is the interaction between Iloprost and Minoxidil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during iloprost initiation and titration. Consider temporarily holding minoxidil during IV iloprost and reduce the iloprost dose if hypotension persists.
What other medicines interact with Minoxidil?
MediHelp also lists interactions of Minoxidil with, for example, Aldesleukin, Amifostine, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Minoxidil page.
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