Drug interactions
Iloprost + Morphine
Severity: Moderate
Iloprost and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloprost is a potent vasodilator, and morphine can cause histamine-mediated vasodilation and hypotension. Together they may produce additive blood pressure lowering.
What this interaction means in plain words
Iloprost and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloprost belongs to Cardiovascular; Morphine belongs to Musculoskeletal.
Why it happens
Additive hypotensive effects from prostacyclin-mediated vasodilation and opioid-related vasodilation.
What to do
Monitor blood pressure, particularly with intravenous iloprost. Reduce the iloprost dose or adjust other blood pressure-lowering drugs if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Iloprost
- Aldesleukin + Iloprost Moderate
- Amiodarone + Iloprost Moderate
- Bortezomib + Iloprost Moderate
- Bromocriptine + Iloprost Moderate
- Bupivacaine + Iloprost Moderate
- Carbidopa-entacapone-levodopa + Iloprost Moderate
Frequently asked questions
Can I take Iloprost with Morphine?
MediHelp rates the interaction as moderate. Iloprost and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloprost is a potent vasodilator, and morphine can cause histamine-mediated vasodilation and hypotension. Together they may produce additive blood pressure lowering.
How serious is the interaction between Iloprost and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, particularly with intravenous iloprost. Reduce the iloprost dose or adjust other blood pressure-lowering drugs if hypotension develops.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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