Drug interactions
Iloprost + Phenelzine
Severity: Moderate
Iloprost and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloprost is a potent vasodilator, and phenelzine often causes orthostatic hypotension. Together they may produce additive hypotension, particularly with intravenous iloprost. Dizziness, syncope and reduced organ perfusion are possible.
What this interaction means in plain words
Iloprost and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloprost belongs to Cardiovascular; Phenelzine belongs to Central Nervous System.
Why it happens
Additive blood pressure lowering through prostacyclin-mediated vasodilation and MAOI-related orthostatic hypotension.
What to do
Monitor blood pressure closely when starting or titrating iloprost. Reduce the iloprost dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Iloprost
- Aldesleukin + Iloprost Moderate
- Amiodarone + Iloprost Moderate
- Bortezomib + Iloprost Moderate
- Bromocriptine + Iloprost Moderate
- Bupivacaine + Iloprost Moderate
- Carbidopa-entacapone-levodopa + Iloprost Moderate
Frequently asked questions
Can I take Iloprost with Phenelzine?
MediHelp rates the interaction as moderate. Iloprost and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloprost is a potent vasodilator, and phenelzine often causes orthostatic hypotension. Together they may produce additive hypotension, particularly with intravenous iloprost. Dizziness, syncope and reduced organ perfusion are possible.
How serious is the interaction between Iloprost and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely when starting or titrating iloprost. Reduce the iloprost dose if hypotension develops.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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