Drug interactions
Imatinib + Isavuconazonium
Severity: Moderate
Imatinib and Isavuconazonium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a CYP3A4 substrate and imatinib may modestly increase its exposure. Isavuconazole is a moderate CYP3A4 inhibitor and may raise imatinib levels in turn. Both effects are generally manageable.
What this interaction means in plain words
Imatinib and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Isavuconazonium belongs to Anti Fungals.
Why it happens
Reciprocal CYP3A4 inhibition: imatinib reduces isavuconazole clearance and isavuconazole inhibits imatinib metabolism.
What to do
Monitor for imatinib adverse effects such as edema and cytopenias, and for isavuconazole adverse effects such as liver enzyme elevation and QT shortening.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Imatinib with Isavuconazonium?
MediHelp rates the interaction as moderate. Imatinib and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole is a CYP3A4 substrate and imatinib may modestly increase its exposure. Isavuconazole is a moderate CYP3A4 inhibitor and may raise imatinib levels in turn. Both effects are generally manageable.
How serious is the interaction between Imatinib and Isavuconazonium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for imatinib adverse effects such as edema and cytopenias, and for isavuconazole adverse effects such as liver enzyme elevation and QT shortening.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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