Drug interactions
Imatinib + Ketoprofen
Severity: Moderate
Imatinib and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib can cause thrombocytopenia and gastrointestinal bleeding, and ketoprofen adds platelet dysfunction and mucosal injury. Together the bleeding risk is increased.
What this interaction means in plain words
Imatinib and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Ketoprofen belongs to Musculoskeletal.
Why it happens
Additive effects on hemostasis: imatinib-induced thrombocytopenia plus NSAID antiplatelet activity and gastric irritation.
What to do
Monitor blood counts and watch for bleeding; prefer paracetamol, and avoid the NSAID if platelet counts are low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Ketoprofen?
MediHelp rates the interaction as moderate. Imatinib and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib can cause thrombocytopenia and gastrointestinal bleeding, and ketoprofen adds platelet dysfunction and mucosal injury. Together the bleeding risk is increased.
How serious is the interaction between Imatinib and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and watch for bleeding; prefer paracetamol, and avoid the NSAID if platelet counts are low.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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