Drug interactions
Imatinib + Lemborexant
Severity: Moderate
Imatinib and Lemborexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib is a CYP3A4 inhibitor and may increase lemborexant exposure. This can cause excess somnolence, next-day impairment and complex sleep behaviors.
What this interaction means in plain words
Imatinib and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Lemborexant belongs to Central Nervous System.
Why it happens
Imatinib inhibits CYP3A4-mediated lemborexant metabolism.
What to do
Avoid the combination where possible, or use a lower lemborexant dose (maximum 5 mg) and monitor for daytime sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Imatinib and Lemborexant, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Lemborexant
Frequently asked questions
Can I take Imatinib with Lemborexant?
MediHelp rates the interaction as moderate. Imatinib and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib is a CYP3A4 inhibitor and may increase lemborexant exposure. This can cause excess somnolence, next-day impairment and complex sleep behaviors.
How serious is the interaction between Imatinib and Lemborexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use a lower lemborexant dose (maximum 5 mg) and monitor for daytime sedation.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
