Drug interactions
Imatinib + Lenacapavir
Severity: Moderate
Imatinib and Lenacapavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor and may raise imatinib concentrations. The inhibitory effect can persist for months after the last subcutaneous dose because of its long half-life.
What this interaction means in plain words
Imatinib and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Lenacapavir belongs to Anti Virals.
Why it happens
Lenacapavir inhibits CYP3A4, decreasing imatinib metabolism.
What to do
Monitor for imatinib adverse effects such as edema, cytopenias and hepatotoxicity, and reduce the imatinib dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Imatinib and Lenacapavir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Imatinib with Lenacapavir?
MediHelp rates the interaction as moderate. Imatinib and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor and may raise imatinib concentrations. The inhibitory effect can persist for months after the last subcutaneous dose because of its long half-life.
How serious is the interaction between Imatinib and Lenacapavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for imatinib adverse effects such as edema, cytopenias and hepatotoxicity, and reduce the imatinib dose if toxicity occurs.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
