Drug interactions
Imatinib + Leniolisib
Severity: Moderate
Imatinib and Leniolisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits BCRP and OATP1B1/1B3 and may raise imatinib exposure. This could increase imatinib adverse effects such as fluid retention, cytopenias and hepatotoxicity.
What this interaction means in plain words
Imatinib and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Leniolisib belongs to Miscellaneous.
Why it happens
Leniolisib inhibits BCRP and OATP transporters involved in imatinib disposition.
What to do
Monitor for imatinib toxicity and blood counts; consider imatinib trough monitoring or dose reduction if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Leniolisib
Frequently asked questions
Can I take Imatinib with Leniolisib?
MediHelp rates the interaction as moderate. Imatinib and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib inhibits BCRP and OATP1B1/1B3 and may raise imatinib exposure. This could increase imatinib adverse effects such as fluid retention, cytopenias and hepatotoxicity.
How serious is the interaction between Imatinib and Leniolisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for imatinib toxicity and blood counts; consider imatinib trough monitoring or dose reduction if adverse effects develop.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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