Drug interactions
Imatinib + Lurbinectedin
Severity: Major
Imatinib and Lurbinectedin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib is a moderate CYP3A4 inhibitor and may increase lurbinectedin exposure. This could worsen myelosuppression, hepatotoxicity and fatigue or nausea.
What this interaction means in plain words
Imatinib and Lurbinectedin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Imatinib belongs to Oncology; Lurbinectedin belongs to Oncology.
Why it happens
Imatinib inhibits CYP3A4, the main pathway of lurbinectedin metabolism.
What to do
Avoid the combination where possible. If it is unavoidable, monitor blood counts and liver tests closely and reduce the lurbinectedin dose per labeling for CYP3A inhibitors.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Lurbinectedin
Frequently asked questions
Can I take Imatinib with Lurbinectedin?
MediHelp rates the interaction as major. Imatinib and Lurbinectedin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Imatinib is a moderate CYP3A4 inhibitor and may increase lurbinectedin exposure. This could worsen myelosuppression, hepatotoxicity and fatigue or nausea.
How serious is the interaction between Imatinib and Lurbinectedin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If it is unavoidable, monitor blood counts and liver tests closely and reduce the lurbinectedin dose per labeling for CYP3A inhibitors.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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