Drug interactions
Imatinib + Naldemedine
Severity: Minor
Imatinib and Naldemedine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naldemedine is a CYP3A4 and P-gp substrate and imatinib may increase its exposure. This may increase gastrointestinal adverse effects such as abdominal pain and diarrhea.
What this interaction means in plain words
Imatinib and Naldemedine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imatinib belongs to Oncology; Naldemedine belongs to Gastrointestinal Tract.
Why it happens
Imatinib inhibits CYP3A4 metabolism of naldemedine.
What to do
Monitor for gastrointestinal adverse effects and reduce or stop naldemedine if they become troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Imatinib with Naldemedine?
MediHelp rates the interaction as minor. Imatinib and Naldemedine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Naldemedine is a CYP3A4 and P-gp substrate and imatinib may increase its exposure. This may increase gastrointestinal adverse effects such as abdominal pain and diarrhea.
How serious is the interaction between Imatinib and Naldemedine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal adverse effects and reduce or stop naldemedine if they become troublesome.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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