Drug interactions
Imatinib + Naloxegol
Severity: Moderate
Imatinib and Naloxegol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib may increase naloxegol exposure through CYP3A4 inhibition. Higher naloxegol levels can precipitate opioid withdrawal and gastrointestinal effects such as abdominal pain and diarrhea. Labeling contraindicates strong CYP3A4 inhibitors, and moderate inhibitors require dose reduction.
What this interaction means in plain words
Imatinib and Naloxegol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Naloxegol belongs to Gastrointestinal Tract.
Why it happens
Imatinib inhibits CYP3A4 and may increase naloxegol concentrations.
What to do
Imatinib is a moderate inhibitor, so reduce naloxegol to 12.5 mg daily and monitor for withdrawal symptoms and abdominal pain. Consider an alternative laxative if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Imatinib and Naloxegol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Naloxegol
- Clarithromycin + Naloxegol Contraindicated
- Itraconazole + Naloxegol Contraindicated
- Ketoconazole + Naloxegol Contraindicated
- Naloxegol + Posaconazole Contraindicated
- Naloxegol + Voriconazole Contraindicated
- Bupropion-naltrexone + Naloxegol Major
Frequently asked questions
Can I take Imatinib with Naloxegol?
MediHelp rates the interaction as moderate. Imatinib and Naloxegol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib may increase naloxegol exposure through CYP3A4 inhibition. Higher naloxegol levels can precipitate opioid withdrawal and gastrointestinal effects such as abdominal pain and diarrhea. Labeling contraindicates strong CYP3A4 inhibitors, and moderate inhibitors require dose reduction.
How serious is the interaction between Imatinib and Naloxegol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Imatinib is a moderate inhibitor, so reduce naloxegol to 12.5 mg daily and monitor for withdrawal symptoms and abdominal pain. Consider an alternative laxative if symptoms occur.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
