Drug interactions
Imatinib + Nebivolol
Severity: Moderate
Imatinib and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP2D6 and may increase nebivolol exposure. This can lead to excess beta-blockade with bradycardia or hypotension.
What this interaction means in plain words
Imatinib and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Nebivolol belongs to Cardiovascular.
Why it happens
Imatinib inhibits CYP2D6-mediated metabolism of nebivolol.
What to do
Monitor heart rate and blood pressure after imatinib is started. Reduce the nebivolol dose if symptomatic bradycardia or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Nebivolol?
MediHelp rates the interaction as moderate. Imatinib and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib inhibits CYP2D6 and may increase nebivolol exposure. This can lead to excess beta-blockade with bradycardia or hypotension.
How serious is the interaction between Imatinib and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure after imatinib is started. Reduce the nebivolol dose if symptomatic bradycardia or hypotension occurs.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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