Drug interactions
Imatinib + Nicardipine
Severity: Moderate
Imatinib and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine may raise imatinib exposure by inhibiting efflux transport, and imatinib inhibits CYP3A4 and may raise nicardipine levels. Both effects are probably modest.
What this interaction means in plain words
Imatinib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Nicardipine belongs to Cardiovascular.
Why it happens
Inhibition of P-glycoprotein efflux of imatinib by nicardipine, with imatinib inhibiting CYP3A4.
What to do
Monitor for imatinib adverse effects such as edema and cytopenias, and monitor blood pressure. Adjust doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Nicardipine?
MediHelp rates the interaction as moderate. Imatinib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine may raise imatinib exposure by inhibiting efflux transport, and imatinib inhibits CYP3A4 and may raise nicardipine levels. Both effects are probably modest.
How serious is the interaction between Imatinib and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for imatinib adverse effects such as edema and cytopenias, and monitor blood pressure. Adjust doses as needed.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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