Drug interactions
Imatinib + Oliceridine
Severity: Moderate
Imatinib and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oliceridine is metabolized by CYP3A4 and CYP2D6, both of which imatinib inhibits. Higher oliceridine levels may cause excessive sedation and respiratory depression.
What this interaction means in plain words
Imatinib and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Oliceridine belongs to Musculoskeletal.
Why it happens
Imatinib inhibits CYP3A4 and CYP2D6, decreasing oliceridine metabolism.
What to do
Monitor for sedation and respiratory depression, and use less frequent or lower oliceridine doses. If imatinib is stopped, watch for reduced analgesia or opioid withdrawal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Imatinib with Oliceridine?
MediHelp rates the interaction as moderate. Imatinib and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oliceridine is metabolized by CYP3A4 and CYP2D6, both of which imatinib inhibits. Higher oliceridine levels may cause excessive sedation and respiratory depression.
How serious is the interaction between Imatinib and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression, and use less frequent or lower oliceridine doses. If imatinib is stopped, watch for reduced analgesia or opioid withdrawal.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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