Drug interactions
Imatinib + Pemigatinib
Severity: Moderate
Imatinib and Pemigatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib may increase pemigatinib exposure, increasing hyperphosphatemia, eye toxicity and other adverse effects.
What this interaction means in plain words
Imatinib and Pemigatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Pemigatinib belongs to Oncology.
Why it happens
Imatinib inhibits CYP3A4, which metabolizes pemigatinib.
What to do
Reduce the pemigatinib dose per labeling for moderate CYP3A inhibitors and monitor serum phosphate and ophthalmic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Pemigatinib
Frequently asked questions
Can I take Imatinib with Pemigatinib?
MediHelp rates the interaction as moderate. Imatinib and Pemigatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib may increase pemigatinib exposure, increasing hyperphosphatemia, eye toxicity and other adverse effects.
How serious is the interaction between Imatinib and Pemigatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the pemigatinib dose per labeling for moderate CYP3A inhibitors and monitor serum phosphate and ophthalmic symptoms.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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