Drug interactions
Imatinib + Prasugrel
Severity: Moderate
Imatinib and Prasugrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib can cause thrombocytopenia and other cytopenias, and prasugrel is a potent antiplatelet agent. Together they raise the risk of clinically significant bleeding.
What this interaction means in plain words
Imatinib and Prasugrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Prasugrel belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effect on hemostasis: imatinib-related thrombocytopenia plus irreversible P2Y12 platelet inhibition.
What to do
Monitor platelet counts and for bleeding signs regularly. Reassess the need for prasugrel if platelets fall substantially or bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Prasugrel
Frequently asked questions
Can I take Imatinib with Prasugrel?
MediHelp rates the interaction as moderate. Imatinib and Prasugrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib can cause thrombocytopenia and other cytopenias, and prasugrel is a potent antiplatelet agent. Together they raise the risk of clinically significant bleeding.
How serious is the interaction between Imatinib and Prasugrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and for bleeding signs regularly. Reassess the need for prasugrel if platelets fall substantially or bleeding occurs.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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