Drug interactions
Imatinib + Propafenone
Severity: Moderate
Imatinib and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP2D6 and CYP3A4 and may raise propafenone concentrations. Higher levels increase the risk of conduction slowing, bradycardia and arrhythmia. Imatinib can also contribute to QT prolongation in some patients.
What this interaction means in plain words
Imatinib and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Propafenone belongs to Cardiovascular.
Why it happens
Imatinib inhibits CYP2D6 and CYP3A4 metabolism of propafenone.
What to do
Monitor ECG and heart rate when starting imatinib, and lower the propafenone dose if QRS or PR prolongation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Propafenone?
MediHelp rates the interaction as moderate. Imatinib and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib inhibits CYP2D6 and CYP3A4 and may raise propafenone concentrations. Higher levels increase the risk of conduction slowing, bradycardia and arrhythmia. Imatinib can also contribute to QT prolongation in some patients.
How serious is the interaction between Imatinib and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate when starting imatinib, and lower the propafenone dose if QRS or PR prolongation occurs.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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