Drug interactions
Imatinib + Quinidine
Severity: Moderate
Imatinib and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine inhibits P-glycoprotein and may modestly increase imatinib exposure. Imatinib can also prolong the QT interval, adding to quinidine's proarrhythmic potential.
What this interaction means in plain words
Imatinib and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Quinidine belongs to Anti Parasitic.
Why it happens
P-glycoprotein inhibition by quinidine raises imatinib absorption and reduces its efflux, with additive QT effects.
What to do
Monitor ECG (QTc) and imatinib adverse effects such as edema and cytopenias. Correct electrolytes and reduce the imatinib dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Quinidine?
MediHelp rates the interaction as moderate. Imatinib and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine inhibits P-glycoprotein and may modestly increase imatinib exposure. Imatinib can also prolong the QT interval, adding to quinidine's proarrhythmic potential.
How serious is the interaction between Imatinib and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG (QTc) and imatinib adverse effects such as edema and cytopenias. Correct electrolytes and reduce the imatinib dose if toxicity develops.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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