Drug interactions
Imatinib + Ramelteon
Severity: Minor
Imatinib and Ramelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib may modestly increase ramelteon exposure by inhibiting enzymes that metabolize it. Increased drowsiness or dizziness could result, but the effect is predicted rather than well documented.
What this interaction means in plain words
Imatinib and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imatinib belongs to Oncology; Ramelteon belongs to Central Nervous System.
Why it happens
Imatinib inhibits CYP enzymes (including CYP2C9 and CYP3A4) that contribute to ramelteon metabolism.
What to do
Monitor for excess sedation when the two are used together. Lower the ramelteon dose if adverse effects develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Ramelteon?
MediHelp rates the interaction as minor. Imatinib and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Imatinib may modestly increase ramelteon exposure by inhibiting enzymes that metabolize it. Increased drowsiness or dizziness could result, but the effect is predicted rather than well documented.
How serious is the interaction between Imatinib and Ramelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation when the two are used together. Lower the ramelteon dose if adverse effects develop.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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