Drug interactions
Imatinib + Riociguat
Severity: Moderate
Imatinib and Riociguat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib may increase riociguat exposure by inhibiting its metabolism and efflux. This can cause excessive vasodilation with symptomatic hypotension.
What this interaction means in plain words
Imatinib and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Riociguat belongs to Cardiovascular.
Why it happens
Imatinib inhibits CYP3A4, P-glycoprotein and BCRP, which clear riociguat.
What to do
Consider a lower riociguat starting dose of 0.5 mg three times daily. Monitor blood pressure and reduce the dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
Frequently asked questions
Can I take Imatinib with Riociguat?
MediHelp rates the interaction as moderate. Imatinib and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib may increase riociguat exposure by inhibiting its metabolism and efflux. This can cause excessive vasodilation with symptomatic hypotension.
How serious is the interaction between Imatinib and Riociguat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower riociguat starting dose of 0.5 mg three times daily. Monitor blood pressure and reduce the dose if hypotension occurs.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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