Drug interactions
Imatinib + Saxagliptin-metformin
Severity: Minor
Imatinib and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP3A4 and may increase saxagliptin exposure, though it is a moderate rather than strong inhibitor. Saxagliptin adverse effects could be more likely.
What this interaction means in plain words
Imatinib and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imatinib belongs to Oncology; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated saxagliptin metabolism.
What to do
Monitor glycemic response and saxagliptin adverse effects; consider a 2.5 mg saxagliptin dose if clinically concerned.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Imatinib and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Imatinib inhibits CYP3A4 and may increase saxagliptin exposure, though it is a moderate rather than strong inhibitor. Saxagliptin adverse effects could be more likely.
How serious is the interaction between Imatinib and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic response and saxagliptin adverse effects; consider a 2.5 mg saxagliptin dose if clinically concerned.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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