Drug interactions
Imatinib + Selexipag
Severity: Minor
Imatinib and Selexipag: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib may inhibit BCRP and CYP enzymes involved in selexipag disposition, and could raise exposure to selexipag or its active metabolite. This could increase adverse effects such as headache, diarrhea, nausea and jaw pain.
What this interaction means in plain words
Imatinib and Selexipag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imatinib belongs to Oncology; Selexipag belongs to Cardiovascular.
Why it happens
Possible inhibition of BCRP-mediated efflux by imatinib, increasing selexipag exposure.
What to do
Monitor for selexipag adverse effects such as hypotension and gastrointestinal symptoms and adjust the dose to tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Selexipag
- Gemfibrozil + Selexipag Contraindicated
- Abiraterone + Selexipag Moderate
- Apalutamide + Selexipag Moderate
- Carbamazepine + Selexipag Moderate
- Clopidogrel + Selexipag Moderate
- Cyclosporin + Selexipag Moderate
Frequently asked questions
Can I take Imatinib with Selexipag?
MediHelp rates the interaction as minor. Imatinib and Selexipag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Imatinib may inhibit BCRP and CYP enzymes involved in selexipag disposition, and could raise exposure to selexipag or its active metabolite. This could increase adverse effects such as headache, diarrhea, nausea and jaw pain.
How serious is the interaction between Imatinib and Selexipag?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for selexipag adverse effects such as hypotension and gastrointestinal symptoms and adjust the dose to tolerability.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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