Drug interactions
Imatinib + Sparsentan
Severity: Moderate
Imatinib and Sparsentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan is a CYP3A4 inducer (weak to moderate) and could reduce imatinib concentrations, with the potential for reduced efficacy. The extent is not well characterized. Sparsentan also carries hepatotoxicity risk that overlaps with imatinib.
What this interaction means in plain words
Imatinib and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Sparsentan belongs to Genitourinary.
Why it happens
Sparsentan induces CYP3A4, increasing imatinib clearance.
What to do
Monitor response to imatinib, consider therapeutic drug monitoring, and check liver enzymes regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Imatinib with Sparsentan?
MediHelp rates the interaction as moderate. Imatinib and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sparsentan is a CYP3A4 inducer (weak to moderate) and could reduce imatinib concentrations, with the potential for reduced efficacy. The extent is not well characterized. Sparsentan also carries hepatotoxicity risk that overlaps with imatinib.
How serious is the interaction between Imatinib and Sparsentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor response to imatinib, consider therapeutic drug monitoring, and check liver enzymes regularly.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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