Drug interactions
Imatinib + Sulindac
Severity: Moderate
Imatinib and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib can cause thrombocytopenia and other cytopenias, and sulindac impairs platelet function and can injure the gastric mucosa. Combined use may increase the risk of bleeding.
What this interaction means in plain words
Imatinib and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Sulindac belongs to Musculoskeletal.
Why it happens
Additive effect on hemostasis: imatinib-related reduced platelet count plus NSAID platelet dysfunction and gastrointestinal mucosal injury.
What to do
Monitor blood counts regularly and watch for bleeding. Prefer paracetamol, and avoid sulindac if platelets are low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Sulindac?
MediHelp rates the interaction as moderate. Imatinib and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib can cause thrombocytopenia and other cytopenias, and sulindac impairs platelet function and can injure the gastric mucosa. Combined use may increase the risk of bleeding.
How serious is the interaction between Imatinib and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts regularly and watch for bleeding. Prefer paracetamol, and avoid sulindac if platelets are low.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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